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UMD TP53 database
A reference for all scientists working on p53, including information on p53 structure and function, the description of all p53 monoclonal antibodies and the phylogenetic analysis of p53. More than 50% of human tumors carry TP53 gene mutations and in consequence more than 45,000 somatic and germline mutations have been gathered in the UMD TP53 database. Analyses of these mutations have been invaluable for bettering our knowledge on the structure-function relationships within the TP53 protein and the high degree of heterogeneity of the various TP53 mutants in human cancer.
HADb / Human Autophagy Database
A public repository containing information about the human genes described so far as involved in autophagy. HADb provides a complete and an up-to-date list of human genes and proteins involved directly or indirectly in autophagy as described in literature. General information, comments and genomic annotations had been used to describe genes. The display of annotations and the navigation on the genome is then possible by using an internal GBrowse or a link to Ensembl.
A dedicated database of 82 apoptosis proteins. ApoCanD comprises of crucial information of apoptosis proteins in the context of cancer. Genomic status of proteins in the form of mutation, copy number variation and expression in thousands of tumour samples and cancer cell lines are the major bricks of this database. Availability of other information e.g. gene essentiality data, tertiary structure, sequence alignments, sequences profiles, post-translational modifications makes it even more useful for the researchers. ApoCanD provides plenty of opportunities for the researchers in exploring the role of apoptosis in cancer.
Provides information about potential caspase cleavage sites in a verified set of human proteins involved in NDs. CaspNeuroD is a relational database of in silico predicted caspase cleavage sites in human proteins associated with NDs. This database could be used for identifying new caspase substrates and further our understanding of the caspase-mediated substrate cleavage in NDs. It provides also information about the conservation of cleavage positions in corresponding orthologs, and information about the positions of single nucleotide polymorphisms and posttranslational modifications (PTMs) that may modulate the caspase cleavage efficiency.
AGIS / Apoptosis Gene Information System
Provides data for over 2400 genes involved directly or indirectly, in apoptotic pathways of more than 350 different organisms. AGIS is to provide the maximum available information for each gene/protein involved in apoptosis and to facilitate researchers in their quest for information directly or indirectly related to apoptotic signal transduction pathways. It aims to become a major resource in understanding the genetics of human apoptosis.
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