A relational database tool for storing, querying, integrating, and downloading molecular profile data on the NCI-60 and other cancer cell types. The newest CellMiner version includes integration of novel databases and tools associated with whole-exome sequencing and protein expression. Included are (i) "Cell line signature" for DNA, RNA, protein, and drugs; (ii) "Cross correlations" for up to 150 input genes, microRNAs, and compounds in a single query; (iii) "Pattern comparison" to identify connections among drugs, gene expression, genomic variants, microRNA, and protein expressions; (iv) "Genetic variation versus drug visualization" to identify potential new drug:gene DNA variant relationships; and (v) "Genetic variant summation" designed to provide a synopsis of mutational burden on any pathway or gene group for up to 150 genes. Together, these tools allow users to flexibly query the NCI-60 data for potential relationships between genomic, molecular, and pharmacologic parameters in a manner specific to the user's area of expertise.
Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA; Systems Research and Applications Corp., Fairfax, VA, USA; HiThru Analytics LLC, Laurel, MD, USA; Developmental Therapeutics Program, DCTD, NCI, NIH, Bethesda, MD, USA