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Here, we surveyed bioinformatics software tools for network centrality inference. The elucidation of whole-cell regulatory, metabolic, interaction and other biological networks generates the need for a meaningful ranking of network elements. Centrality analysis ranks network elements according to their importance within the network structure and different centrality measures focus on different importance concepts. Central elements of biological networks have been found to be, for example, essential for viability.
(Junker et al., 2006) Exploration of biological network centralities with CentiBiN. BMC Bioinformatics.