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MANOR | Spatial normalization of array-CGH data

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A package based on an automatic method for the spatial normalization of array-CGH data. This method makes it possible to delineate and to eliminate and/or correct areas affected by spatial bias. It is based on the combination of a spatial segmentation algorithm called NEM (Neighborhood Expectation Maximization) and spatial trend estimation. MANOR is designed for the spatial normalization of BAC CGH-array data, preventing the misinterpretation of experimental artifacts as biologically relevant outliers in the genomic profile. This method was developed for array-CGH experiments, and gave very good results. However, it can be applied to any microarray experiment having the same types of spatial effect.

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MANOR classification

MANOR specifications

Unique identifier:
OMICS_02028
Software type:
Package/Module
Restrictions to use:
None
Programming languages:
R
Computer skills:
Advanced
Maintained:
Yes
Name:
CGH Micro-Array NORmalization
Interface:
Command line interface
Operating system:
Unix/Linux, Mac OS, Windows
License:
GNU General Public License version 2.0
Stability:
Stable

MANOR distribution

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No versioning.

MANOR support

Documentation

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Publications

Institution(s)

Institut Curie, Service de Bioinformatique, Paris, France

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