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Provides a suite of utilities that cover a range of complex analysis tasks for immunoglobulin (Ig) repertoire sequencing data. Change-O is a suite of utilities that (i) processes the output of V(D)J alignment tools, (ii) assigns clonal clusters to Ig sequences and (iii) reconstructs germline sequences. It also offers applications to import data from the frequently used IMGT/HighV-QUEST tool and a set of utilities to perform basic database operations, such as sorting, filtering and modifying annotations.

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Change-O classification

Change-O specifications

Software type:
Restrictions to use:
Academic or non-commercial use
Programming languages:
Command line interface
Operating system:
Unix/Linux, Mac OS, Windows
Computer skills:

Change-O distribution


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Change-O support


  • Steven Kleinstein <>


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Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA; Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan, Israel

Funding source(s)

Supported by the National Institutes of Health [R01AI104739; T15LM07056, T15LM07056 from National Library of Medicine (NLM)] and by the United States-Israel Binational Science Foundation [2013395].

Link to literature

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