A suite of utilities which provides tools for advanced analyses of large-scale Ig repertoire sequencing data. Change-O includes tools for determining the complete set of Ig variable region gene segment alleles carried by an individual (including novel alleles), partitioning of Ig sequences into clonal populations, creating lineage trees, inferring somatic hypermutation targeting models, measuring repertoire diversity, quantifying selection pressure, and calculating sequence chemical properties. All Change-O tools utilize a common data format, which enables the seamless integration of multiple analyses into a single workflow.

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No open topic.

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Change-O classification

Change-O specifications

Software type:
Restrictions to use:
Academic users only
Computer skills:
Command line interface
Operating system:

Change-O support





Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT; Department of Pathology, Yale University School of Medicine, New Haven, CT; Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan, Israel

Funding source(s)

This work was supported by the National Institutes of Health [R01AI104739, T15LM07056, T15LM07056].

Link to literature

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