Represents a method for the identification of novel candidate drugs of non-small cell lung cancer (NSCLC). This method consists of three steps: (1) first the extraction of possible compounds by checking the chemical-chemical interactions involving approved NSCLC drugs; (2) then these compounds were filtered by an association test and a permutation test; and (3) the remaining compounds were analyzed using a EM algorithm to further select core compounds.
College of Life Science, Shanghai University, Shanghai, China; College of Information Engineering, Shanghai Maritime University, Shanghai, China; School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China; Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
ChenEtAl2017 funding source(s)
Supported by National Natural Science Foundation of China (31371335), Natural Science Foundation of Shanghai (17ZR1412500), Shanghai Sailing Program and The Youth Innovation Promotion Association of Chinese Academy of Sciences (CAS) (2016245).