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Chromatin interaction analysis by paired-end tag software tools

Chromatin interaction analysis by paired-end tag software tools A number of high-throughput methods based on nuclear proximity ligation have been developed to detect genome-wide chromatin interactions, including high-throughput chromosome conformation capture (Hi-C) and chromatin interaction analysis by paired-end tag sequencing (ChIA-PET). While Hi-C was developed to capture all chromatin interactions and is effective for mapping large-scale structures such as chromatin compartments and topologically associated domains, ChIA-PET is emerging as an important experimental method for detecting specific protein-mediated chromatin loops genome-wide at high resolution.
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