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Protein-DNA interactions are involved in many essential biological processes such as transcription, splicing, replication and DNA repair. ChIP-on-chip is a technique that combines chromatin immunoprecipitation with microarray technology. This technique is well suited for a comprehensive analysis of transcription factor binding sites, histone modification patterns, and nucleosome occupancy.
(Oberley et al., 2004) High-throughput screening of chromatin immunoprecipitates using CpG-island microarrays. Methods Enzymol.