A web-based tool for inferring novel miRNA-disease associations based on a complex heterogeneous network (CHN) involving 402 miRNAs and 5080 diseases. CHNmiRD integrates multiple genomic and phenotype data, including protein-protein interaction data, gene ontology data, experimentally verified miRNA-target relationships, disease phenotype information and known miRNA-disease connections. In particular, CHNmiRD displays excellent performance for diseases without any known related miRNAs. Given a disease, CHNmiRD provides a candidate miRNA list and assigns each miRNA a probability score which reflects the correlation between the miRNA and the disease.
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China; Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
CHNmiRD funding source(s)
This work was supported in part by the National Natural Science Foundation of China (Grant Nos. 31500675), the Postdoctoral Foundation of Heilongjiang Province (Grant No. LBH–Z15162), the Natural Science Foundation of Heilongjiang Province (Grant No. QC2013C019) and the Science Foundation of Heilongjiang Provincial Health Department (Grant Nos. 2013126).