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Chromatin segmentation software tools | ChIP sequencing data analysis

Chromatin segmentation software tools | ChIP sequencing data analysis

The segmentation of epigenomes into chromatin states collapses the ChIP-seq tracks and provides an abstract view on the multi-dimensional data. A chromatin state is a recurrent pattern in the abundances of a given set of histone modifications, possibly related to a particular biological function. Chromatin segmentation aims at explaining the observed epigenomic data as a long sequence of a small number of hidden chromatin states.

Source text:
(Mammana and Chung, 2015) Chromatin segmentation based on a probabilistic model for read counts explains a large portion of the epigenome. Genome Biol.

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