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ChroMoS specifications


Unique identifier OMICS_00145
Name ChroMoS
Alternative name Chromatin Modified SNPs
Interface Web user interface
Restrictions to use None
Computer skills Basic
Maintained Yes


  • person_outline Maxim Barenboim

Publication for Chromatin Modified SNPs

ChroMoS citations


A sequence based method to predict the impact of regulatory variants using random forest

BMC Syst Biol
PMCID: 5374684
PMID: 28361702
DOI: 10.1186/s12918-017-0389-1

[…] ption factor (TF) binding sites because it has been revealed that genetic variants occur in transcription factors binding sites can affect cellular phenotype and gene expression []. To mention a few, ChroMos, an integrated web-tool for SNPs classification and prioritization with the combination of genetic and epigenetic data []. HaploReg, another tool based on quantifying the difference between re […]


GWAS for serum galactose deficient IgA1 implicates critical genes of the O glycosylation pathway

PLoS Genet
PMCID: 5328405
PMID: 28187132
DOI: 10.1371/journal.pgen.1006609

[…] he top most associated variants as well as all SNPs in LD with the lead SNP (r2>0.5) at each locus. We annotated these variants using ANNOVAR[], SeattleSeq[], SNPNexus[], FunciSNP[], HaploReg4[], and ChroMos[]. The transcripts whose expressions were correlated with the lead SNPs in cis- or trans- were also identified using available eQTL datasets, including: (1) peripheral blood eQTLs based on met […]


Meta analysis of genome wide association studies discovers multiple loci for chronic lymphocytic leukemia

Nat Commun
PMCID: 4786871
PMID: 26956414
DOI: 10.1038/ncomms10933

[…] To assess chromatin state dynamics, we used Chromos, which utilizes Chip-Seq data from ENCODE on nine cell types: B-lymphoblastoid cells (GM12878), hepatocellular carcinoma cells (HepG2), embryonic stem cells (hESC), erythrocytic leukemia cells […]


Obesity related known and candidate SNP markers can significantly change affinity of TATA binding protein for human gene promoters

BMC Genomics
PMCID: 4686794
PMID: 26694100
DOI: 10.1186/1471-2164-16-S13-S5

[…] ], ACTIVITY [], is-rSNP [], RegulomeDB [], rSNP-MAPPER [], RAVEN [], SELEX_DB [], FunSeq2 [], APEG [], FeatureScan [,], SNPChIPTools [], SNP-MED [], SNAP [], FunciSNP [], SPOT [], rSNP_Guide [,], and ChroMoS [] facilitate the search for candidate SNP markers in terms of ranking of unannotated SNPs by their similarity to biomedical SNP markers in accordance with projections of these SNPs onto whole […]


A genome wide association study of marginal zone lymphoma shows association to the HLA region

Nat Commun
PMCID: 4287989
PMID: 25569183
DOI: 10.1038/ncomms6751

[…] To assess chromatin state dynamics, we used Chromos, which has precomputed data from ENCODE on nine cell types using Chip-Seq experiments. These consist of B-lymphoblastoid cells (GM12878), hepatocellular carcinoma cells (HepG2), embryonic stem […]


On the identification of potential regulatory variants within genome wide association candidate SNP sets

BMC Med Genomics
PMCID: 4066296
PMID: 24920305
DOI: 10.1186/1755-8794-7-34

[…] l. created a functional SNP annotator by incorporating ENCODE TF and histone modification datasets within an R package, FunciSNP, which was subsequently used in a breast cancer GWAS analysis [,]. The ChroMoS web server, on the other hand, facilitates SNP prioritization using genetic and epigenetic data, and predicts differential transcription factor and miRNA binding [].In this study, we introduce […]


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ChroMoS institution(s)
Bioinformatics and Deep-Sequencing Unit, Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
ChroMoS funding source(s)
National Genome Research Network (NGRN) grant (01GS1110) of the German Federal Ministry of Education and Research (BMBF)

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