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CHRONOS specifications


Unique identifier OMICS_10881
Software type Framework/Library
Interface Command line interface
Restrictions to use None
Input data Time series expression data from paired mRNA/miRNA experiments
Operating system Unix/Linux
Computer skills Advanced
Version 1.8.1
Stability Stable
methods, stats, parallel, graphics, BiocGenerics, utils, grDevices, R(>=3.5), RUnit, biomaRt, knitr, foreach, graph, RBGL, RCurl, XML, doParallel, openxlsx, circlize
Maintained Yes


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  • person_outline Anastasios Bezerianos <>

Publication for CHRONOS

CHRONOS in publications

PMCID: 5931537
PMID: 29717130
DOI: 10.1038/s41467-018-04146-3

[…] chr2-expressing sgns indicated a strong limitation of the temporal response fidelity. therefore, fast chrs are needed and their benefit for use in auditory research has already been indicated using chronos, a “fast” blue light absorbing chr, for stimulation of the cochlear nucleus., electrical cochlea implants (eci), to date, enable speech understanding in most of approximately 500,000 […]

PMCID: 5928259
PMID: 29740286
DOI: 10.3389/fncel.2018.00111

[…] higher than those usually reported for catch (). however, using the vector introduced here for neuron-specific expression in the gerbil brain together with faster channelrhodopsins such as chronos (), it should be possible to bring stimulation frequencies closer to the physiological maxima of auditory neurons., the recorded nphr3.0 photocurrents recorded here, and their kinetics, match […]

PMCID: 5910383
PMID: 29679025
DOI: 10.1038/s41598-018-24892-0

[…] from cyagen (ca, usa), thawed and cultured as described in detail elsewhere. 2 × 105 at-mscs (passage 6) were seeded onto 0.5 ml of β-tcp scaffold granules (0.7–1.4 mm diameter with 60% porosity) (chronos, synthes, switzerland)- soaked in growing medium for at least 16 hours before seeding, and placed in 6-well plates. in the in vitro and in vivo experiments the amount of scaffold material […]

PMCID: 5892872
PMID: 29634740
DOI: 10.1371/journal.pone.0195261

[…] constructs, it has promising osteoconductive characteristics. β-tcp has higher solubility than hap, is degradable via osteoclastic activity, and is used commercially as conduit tcp granules and chronos strips (depuy orthopaedics) [, ]. ceramics containing both β-tcp and hap, termed biphasic calcium phosphates (bcps), are desirable for bone regeneration because their degradation […]

PMCID: 5887132
PMID: 29618589
DOI: 10.1534/genetics.117.300228

[…] their electrophysiological properties. variants exist that increase cation conductance or photocurrent amplitude (catch, chief, chr2-xxl, and chr2-tc), increase onset and offset kinetics (cheta or chronos), and switch them between bistable open and closed states with different wavelengths of light (step-opsins). chronos () and chr2-xxl () show increased light sensitivity in larvae and adults., […]

CHRONOS institution(s)
Department of Computer Engineering and Informatics, University of Patras, Patras, Greece; Department of Medical Physics, School of Medicine, University of Patras, Patras, Greece; Centre for Cancer Biomarkers (CCBIO) and Computational Biology Unit (CBU), Department of Informatics, University of Bergen, Norway; SINAPSE Institute, Center of Life Sciences, National University of Singapore, Singapore
CHRONOS funding source(s)
This research has been cofinanced by the European Union (European Social Fund 6 ESF) and Greek national funds through the Operational Program “Education and Lifelong Learning” of the National Strategic Reference Framework (NSRF) - Research Funding Program: Thalis. Investing in knowledge society through the European Social Fund (grant number: MIS: 377001).

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