A highly scalable, ultra-fast and fully automated analysis pipeline for the discovery of genetic variation. Through implementation of novel deterministic parallelization techniques, Churchill allows computationally efficient analysis of a high-depth whole genome sample in less than two hours. The method is highly scalable, enabling full analysis of the 1000 Genomes raw sequence dataset in a week using cloud resources.
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Center for Microbial Pathogenesis, The Research Institute at Nationwide Children’s Hospital, 700 Children’s Drive, Columbus 43205, OH, USA
This work was supported by Nationwide Children’s Hospital Foundation, the Amazon Web Services in Education Research Grants program, and resource allocation awards from Ohio Supercomputing Center (OSC) and NSF XSEDE Pittsburgh Supercomputing Center (PSC).