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CLAHE specifications


Unique identifier OMICS_25627
Alternative name Enhance Local Contrast
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Java
License GNU General Public License version 2.0
Computer skills Medium
Stability Stable
Maintained Yes



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  • person_outline Stephan Saalfeld <>

CLAHE in pipelines

PMCID: 4769224
PMID: 26919712
DOI: 10.1371/journal.pone.0150170

[…] to preserve meta data []. it then completed the following set of functions with settings based on which protein was imaged (tdtomato or egfp): subtracted background, enhanced local contrast (clahe), set autothreshold, and converted to binary. once in binary, the areas of the image containing no tissue were filled with yellow. the result was a binary image in which white represents tissue […]

PMCID: 4749568
PMID: 26670546
DOI: 10.7554/eLife.11147.029

[…] we discuss in more detail the implications of the circuitry and compare it to the olfactory circuitry in drosophila., g) in , contrast seems optimized to detect immunogold particles. processing with clahe would better reveal cytoplasmic membranes while still preserving the saliency of immunogold particles. what was the algorithm chosen for improving contrast? , the contrast on the images […]

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CLAHE in publications

PMCID: 5865161
PMID: 29572440
DOI: 10.1038/s41467-018-03574-5

[…] microscopy. furthermore, an equalization of the histogram was performed to reduce fluctuation of intensity frame by frame. the largely known contrast limited adaptive histogram equalization (clahe) method has been used from the open source image analysis platform (icy software)., tissue elongation was measured by the ap to dv length ratio of s9 and s10 egg chambers., for quantification […]

PMCID: 5897727
PMID: 29590636
DOI: 10.1242/dmm.032219

[…] cross-section analyses were performed in digitally resliced images of cellmask-stained pnps. cellmask signal was digitally enhanced postacquisition using sequential local contrast enhancement (clahe) in fiji (block size 50, histogram bins 150, maximum slope 3, then repeated with block size 30, histogram bins 100, maximum slope 3) with 30-pixel rolling ball radius background subtraction […]

PMCID: 5809116
PMID: 29432464
DOI: 10.1371/journal.pone.0192203

[…] to its prominent vascular contrast., mask creation from red channel to extract a region of interest (roi)., image contrast enhancement performed by contrast limited adaptive histogram equalization (clahe) and morphological filters have been utilized to eradicate low frequency noise/entities like optic disc, macula, etc., high boost filter has been applied to enhance the edges of thick vessels […]

PMCID: 5797983
PMID: 29363979
DOI: 10.1021/acs.jpclett.7b02831

[…] velocity vectors, we analyzed videos of evaporating droplets with particle image velocimetry (piv). first, the videos’ contrast was enhanced using contrast limited adaptive histogram equalization (clahe), and then piv was performed on the enhanced videos using pivlab with an fft deformation method applied sequentially with 64 × 64, 32 × 32 and 16 × 16 pixel interrogation windows to improve […]

PMCID: 5736696
PMID: 29259241
DOI: 10.1038/s41598-017-18099-y

[…] preparation), is identified in fig.  with a white arrow. some dna trails had dim intensity; therefore, the first step is to enhance contrast with contrast limited adaptive histogram equalization (clahe). six morphological features were derived as discussed in in vitro computational pipeline section of the methods, and table  presents the resulting distributions. convex area, area convexity […]

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