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Gene expression profiling based on microarray technology has been applied widely on monitoring global transcriptome changes in biological samples. In cancer research, one of the major microarray applications is to identify genes, or features, whose expression patterns can discriminate samples with distinct states (usually defined by the phenotype of samples such as primary or metastatic tumour).
(Jen et al., 2008) Signature Evaluation Tool (SET): a Java-based tool to evaluate and visualize the sample discrimination abilities of gene expression signatures. BMC Bioinformatics.