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Clipping REveals STructure CREST

An algorithm using NGS reads with partial alignments to a reference genome to directly map structural variations at the nucleotide level. Application of CREST to whole-genome sequencing data from five pediatric T-lineage acute lymphoblastic leukemias (T-ALLs) and a human melanoma cell line, COLO-829, identified 160 somatic structural variations. Experimental validation exceeded 80%, demonstrating that CREST had a high predictive accuracy.

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CREST classification

CREST specifications

Interface:
Web user interface
Computer skills:
Basic
Maintained:
Yes
Restrictions to use:
None
Stability:
Stable

CREST distribution

Credits

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Publications

Institution(s)

Department of Information Sciences, St. Jude Children’s Research Hospital, Memphis, TN, USA; Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA; Pediatric Cancer Genome Project, St Jude Children’s Research Hospital, Memphis, TN, USA; Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

Link to literature

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