Cloe HIA specifications

Unique identifier:
OMICS_16053
Interface:
Graphical user interface
Input data:
A simple set of early ADME and physicochemical data (aqueous solubility at one or more pH, Caco-2 apparent permeability coefficient, pKa log value(s), Log P).
Output format:
PDF, XLS
Computer skills:
Medium
Maintained:
Yes
Software type:
Package/Module
Restrictions to use:
License purchase required
Output data:
The predicted total absorption at several user-specified dose levels, the identification of factors (solubility and/or permeability) limiting absorption at any poorly absorbed dose level(s), the predicted dependence of the solubility on pH, the predicted absorption from the different segments of the GI tract at each dose level, the predicted time course data representing absorption over time, the predicted solubility over the pH range of the gastrointestinal tract, the peak concentration of compound achieved in the different parts of the tract.
Operating system:
Unix/Linux
Stability:
Stable

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Cloe HIA support

Maintainer

  • DDI-Fusion Team <>

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Credits

Institution(s)

Cyprotex, Nether Alderley, Cheshire, UK

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