Cloe PK specifications

Information


Unique identifier OMICS_16052
Name Cloe PK
Software type Package/Module
Interface Graphical user interface
Restrictions to use License purchase required
Input data LogP (octanol/water) and pKa, microsomal intrinsic clearance, fraction unbound in plasma, blood to plasma ratio (optional), aqueous solubility, caco-2 permeability.
Output data Concentration time profiles in venous and arterial plasma, concentration time profiles in 14 organs and tissues, summary pharmacokinetic parameters.
Output format PDF, XLS
Operating system Unix/Linux
Computer skills Medium
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
    • Rattus norvegicus

Versioning


No version available

Maintainer


  • person_outline DDI-Fusion Team

Cloe PK citation

library_books

Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice

2015
PMCID: 4954844
PMID: 25663650
DOI: 10.1007/s13318-015-0260-y

[…] n from in vitro data have resulted in more frequent use of these models (Jones et al. ; Parrott et al. ). Moreover, several PBPK simulation tools have become commercially available (e.g., GastroPlus, Cloe PK, or PK-Sim).In the present study, this approach was used to evaluate plasma pharmacokinetics and tissue distribution of a drug candidate, LSF, in mice. The mean LSF concentration–time profiles […]

Cloe PK institution(s)
Cyprotex, Nether Alderley, Cheshire, UK

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