Cloe PK statistics

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Associated diseases

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Cloe PK specifications

Information


Unique identifier OMICS_16052
Name Cloe PK
Software type Package/Module
Interface Graphical user interface
Restrictions to use License purchase required
Input data LogP (octanol/water) and pKa, microsomal intrinsic clearance, fraction unbound in plasma, blood to plasma ratio (optional), aqueous solubility, caco-2 permeability.
Output data Concentration time profiles in venous and arterial plasma, concentration time profiles in 14 organs and tissues, summary pharmacokinetic parameters.
Output format PDF, XLS
Operating system Unix/Linux
Computer skills Medium
Stability Stable
Maintained Yes

Taxon


  • Primates
    • Homo sapiens
  • Rodents
    • Mus musculus
    • Rattus norvegicus

Versioning


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Maintainer


  • person_outline DDI-Fusion Team <>

Cloe PK in publication

PMCID: 4954844
PMID: 25663650
DOI: 10.1007/s13318-015-0260-y

[…] from in vitro data have resulted in more frequent use of these models (jones et al. ; parrott et al. ). moreover, several pbpk simulation tools have become commercially available (e.g., gastroplus, cloe pk, or pk-sim)., in the present study, this approach was used to evaluate plasma pharmacokinetics and tissue distribution of a drug candidate, lsf, in mice. the mean lsf concentration–time […]


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Cloe PK institution(s)
Cyprotex, Nether Alderley, Cheshire, UK

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