CLUMP specifications

Information


Unique identifier OMICS_19626
Name CLUMP
Alternative name CLUstering by Mutation Position
Software type Application/Script
Restrictions to use None
Programming languages Python, Shell (Bash)
License MIT License
Computer skills Advanced
Stability Stable
Requirements
python, numpy, scipy, the R library package 'fpc’
Maintained Yes

Download


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Versioning


No version available

Maintainer


  • person_outline Rachel Karchin

Additional information


http://karchinlab.org/apps/appClump.html

Publication for CLUstering by Mutation Position

CLUMP citation

library_books

Hotspots of missense mutation identify novel neurodevelopmental disorder genes and functional domains

2017
Nat Neurosci
PMCID: 5539915
PMID: 28628100
DOI: 10.1038/nn.4589

[…] e mutation will become more transparent and may be better understood in the context of protein structure. PTPN11, associated with Noonan syndrome, is predicted, for example, to have three clusters by CLUMP and 3D protein structure analysis reveals that these three clusters define the cleft of the ligand binding site ().It is interesting that genes associated with hotspots of missense mutation () a […]

CLUMP institution(s)
Predoctoral Training Program in Human Genetics and Molecular Biology, McKusick-Nathans Institute of Genetic Medicine, Baltimore, MD, USA; Center for Complex Disease Genomics, Baltimore, MD, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA; Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
CLUMP funding source(s)
Supported by a grant from the (national science foundation) NSF (DBI-0845275).

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