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Clustering is a well-established technique in the context of gene expression analysis and coexpression studies. Intensity-based clustering by analogy aims to group similar intensity profiles in order to identify interesting groups of marker candidates and visualize them in a convenient way. A major problem with the application of clustering algorithms is that an adequate number of clusters can often not be inferred automatically
(Kaever et al., 2009) MarVis: a tool for clustering and visualization of metabolic biomarkers. BMC Bioinformatics.