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CMPD specifications

Information


Unique identifier OMICS_06406
Name CMPD
Alternative name Cancer Mutant Proteome Database
Restrictions to use None
Maintained Yes

Taxon


  • Primates
    • Homo sapiens

Publication for Cancer Mutant Proteome Database

CMPD citations

 (10)
library_books

β Arrestin1 and 2 differentially regulate PACAP induced PAC1 receptor signaling and trafficking

2018
PLoS One
PMCID: 5937772
PMID: 29734363
DOI: 10.1371/journal.pone.0196946

[…] r 24 h, the cells were subcultured into 96 well plates with Opti-MEM reduced Serum Medium (Life Technologies, Carlsbad, CA, USA). 30 μM G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) inhibitor CMPD101, 20 μM protein kinase A inhibitor H89 or 50 μM protein kinase C inhibitor sphingosine were pretreated for 30 min. Before PACAP treatment, Nano-Glo Live Cell Reagent (Promega) was added and bas […]

library_books

CMPD1 inhibited human gastric cancer cell proliferation by inducing apoptosis and G2/M cell cycle arrest

2018
PMCID: 5901880
PMID: 29661232
DOI: 10.1186/s40659-018-0159-6

[…] The cells (5 × 105) supplemented with 10% FBS were seeded in six-well plates and treated with CMPD1 at various concentrations (0.3, 1, 3, 10 μM) for 24 and 48 h. Cells were harvested and rinsed with cold PBS twice, then incubated with an Annexin V-FITC and PI apoptosis detection kit. Samples w […]

library_books

Modelling and simulation of biased agonism dynamics at a G protein coupled receptor

2018
J Theor Biol
PMCID: 5811930
PMID: 29337260
DOI: 10.1016/j.jtbi.2018.01.010

[…] ccessible, such that μj,θ=kGTP+j,θ=0 are fixed for j ≠ θ, since these have been shown to largely have little effect. Fitted parameters for the NECA data set were used as initial parameter guesses for Cmpd6 and Cmpd20, to speed up the overall fitting for these compounds. For each ligand, the model can clearly fit the data very well qualitatively. In , we see that the model fit for the stimulation c […]

library_books

Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials

2018
PLoS Biol
PMCID: 5779714
PMID: 29320492
DOI: 10.1371/journal.pbio.2003887

[…] operties, and drug-like characteristics, the top 20 compounds were selected for further analysis. Eleven out of these 20 compounds were purchased for further bioactivity testing (, ). Five compounds (cmpd2, cmpd4, cmpd8, cmpd10, cmpd11) could inhibit the GTPase activity of UreG by 37% to 72%; subsequent urease assays showed that two compounds (cmpd4, cmpd8) exhibited very good activity (by ca. 60% […]

library_books

HDX reveals the conformational dynamics of DNA sequence specific VDR co activator interactions

2017
Nat Commun
PMCID: 5640644
PMID: 29030554
DOI: 10.1038/s41467-017-00978-7

[…] coside), 5 mM Bme (beta mercaptoethanol)).The protein was purified by Ni-NTASEC and stored in final protein buffer 50 mM Tris (pH 8.0), 150 mM NaCl, 10% glycerol and 2 mM DTT. Crystals of the protein/Cmpd 3 complex (PDB code: 5V39) were grown by vapor diffusion with a well solution of 100 mM Tris-HCl pH 8.5, 25% PEG 3350 and 200 mM Ammonium Sulfate (reservoir buffer). Crystallization tray was set- […]

library_books

Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells

2017
Sci Rep
PMCID: 5578959
PMID: 28860483
DOI: 10.1038/s41598-017-10501-z

[…] esulting list of phosphorylation sites exported from the MaxQuant software was filtered for class-I sites, i.e. phosphorylation sites that could be located with high confidence. For the comparison of cmpd versus DMSO treated PBMC the ratios were calculated via the respective pooled reference sample (light mTRAQ label) for each individual replicate experiment and a hypothesis test was conducted to […]

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CMPD institution(s)
Bioinformatics Core Laboratory, Chang Gung University, Taoyuan, Taiwan; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan; Bioinformatics Division, Tri-I Biotech, Inc, Taipei, Taiwan; Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Lin-Kou, Taoyuan, Taiwan; Department of Molecular and Cellular Biology, Chang Gung University, Taoyuan, Taiwan

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