CNS pipeline

CNS specifications

Information


Unique identifier OMICS_15605
Name CNS
Alternative name Crystallography & NMR System
Software type Package/Module
Interface Graphical user interface
Restrictions to use Academic or non-commercial use
Operating system Unix/Linux, Mac OS
Programming languages Fortran
Computer skills Medium
Version 1.3
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Axel Brunger <>

Publications for Crystallography & NMR System

CNS IN pipelines

 (34)
2017
PMCID: 5814841
PMID: 29294091
DOI: 10.1093/nar/gkx1275

[…] provided at the last iteration of the aria 2.3 protocol were further manually verified by multiple steps of the structure refinement accomplished using the simulated annealing protocol of the cns 1.21 software package (60). structure refinement included a high-temperature torsion-angle molecular dynamics stage followed by a slow-cooling torsion-angle phase, a second slow-cooling phase […]

2017
PMCID: 5814841
PMID: 29294091
DOI: 10.1093/nar/gkx1275

[…] structure refinement was performed until no noe violations >0.2 å and no dihedral angle violations higher than 5° occurred. the restraint violations and structure quality were assessed using the cns tools, procheck-nmr (62) and in-house software and utilities. at the last iteration of the refinement protocol 100 structures have been calculated using 1577 unambiguous distance and 199 dihedral […]

2017
PMCID: 5870574
PMID: 28881974
DOI: 10.1093/bioinformatics/btx239

[…] with model quality assessment is complementary to using larger sequence databases and a more extensive folding procedure. table 4.0.010.1proq3d36 (10)225 (75)pcombc42 (21)179 (74)pcons18 (9)218 (91)cns-contact62 (13)232 (38)union114 (35)558 (143)all6379 (558)6379 (558), in table 5, it can be seen that the average length of the successfully predicted models is shorter than for the average length […]

2016
PMCID: 4742562
PMID: 26903974
DOI: 10.3389/fmicb.2016.00095

[…] was used for visualization of spectra, resonance connectivity analysis, and distance restraints (noe) assignments. structure calculations were performed using an iterative procedure within the aria/cns suite of programs (brunger et al., 1998). the assessment of the quality of the nmr generated structural models, were performed using the protein structure validation suite (psvs, table 3; […]

2016
PMCID: 5045296
PMID: 27690357
DOI: 10.7554/eLife.18101.033

[…] program package (otwinowski and minor, 1997) was used to index, integrate and scale the data. the structure of 353wt was solved by molecular replacement using the crystallography & nmr system (cns) (brunger, 2007; brünger et al., 1998) and the atomic coordinates of kif18amd (pdb: 3lre) as a search model. several rounds of iterative model building and refinement were performed using coot […]

CNS institution(s)
The Howard Hughes Medical Institute and Departments of Molecular and Cellular Physiology, Neurology and Neurological Sciences, Structural Biology, and Photon Science, Stanford University, CA, USA

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