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chevron_left Sequence-based B-cell epitope prediction chevron_right
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COBEpro specifications

Information


Unique identifier OMICS_05746
Name COBEpro
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Pierre Baldi <>

Publication for COBEpro

COBEpro in publications

 (16)
PMCID: 5862889
PMID: 29563531
DOI: 10.1038/s41598-018-23029-7

[…] in the studied genomes were taken from orthomcl results., sequences of immunoreactive proteins were searched for potential epitopes using 15 predictive approaches: aap, bcpred, bepipred, cbtope, cobepro, fbcpred, igpred, svmtrip, as well as bcepred based on seven amino acid physico-chemical scales, hydrophilicity, flexibility, accessibility, turns, antigenic propensity, exposed residues […]

PMCID: 5450216
PMID: 28558675
DOI: 10.1186/s12896-017-0370-5

[…] of continuous b-cell epitopes was carried out on eight full-length vp2 amino acid sequences that were available on genbank at the time of the study (http://www.ncbi.nlm.nih.gov/genbank) with cobepro [] prediction software available from the scratch protein server (http://scratch.proteomics.ics.uci.edu/). the 8 vp2 amino acid sequences were aligned and two predicted b-cell epitope regions […]

PMCID: 5227168
PMID: 28127568
DOI: 10.1155/2016/6760830

[…] achieves auc at 0.81 and 0.85 for the fragment-based prediction and 0.57 and 0.6 for full antigen. best outperforms several modern sequence-based b-cell epitope predictors including abcpred, bcpred, cobepro, and cbtope []., svmtrip employs support vector machine to combine the tripeptide similarity and propensity scores to predict linear epitopes. svmtrip achieves a sensitivity of 80.1% […]

PMCID: 5104390
PMID: 27832200
DOI: 10.1371/journal.pone.0166372

[…] this software allows prediction of promiscuous hla class ii binders that can bind to a large number of alleles., there are numerous methods such as bcepred [], cbtope [], lbtope [], discotope [], cobepro [] available for predicting b-cell epitopes. we employed a standalone version of lbtope software for the prediction of linear b-cell epitopes. in order to predict immune epitopes in the query […]

PMCID: 4875615
PMID: 27206475
DOI: 10.1186/s12879-016-1552-9

[…] amino acid properties, including immunoinformatic analysis and prediction of b-cell epitopes, such as hydrophilicity [], surface accessibility [], secondary structure [], flexibility [], abcpred [], cobepro [], and bepipred []. with the development of these bioinformatics methods, they provide more cost-effective approaches for seeking brucella vaccines and brucellosis diagnostic antigens., […]


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