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COFACTOR

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A structure-based method for biological function annotation of protein molecules. To use COFACTOR, user needs to provide a 3D-structural model of the protein of interest. COFACTOR will thread the structure through the BioLiP protein function database by local and global structure matches to identify functional sites and homologies. Functional insights, including ligand-binding site, gene-ontology terms, and enzyme classification, will be derived from the best functional homology template.

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COFACTOR classification

COFACTOR specifications

Software type:
Package/Module
Restrictions to use:
None
Input format:
PDB
Computer skills:
Advanced
Maintained:
Yes
Interface:
Command line interface
Input data:
Protein structure
Operating system:
Unix/Linux
Stability:
Stable

COFACTOR distribution

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COFACTOR forum

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No open topic.

COFACTOR classification

COFACTOR specifications

Interface:
Web user interface
Input data:
Protein structure
Computer skills:
Basic
Maintained:
Yes
Restrictions to use:
None
Input format:
PDB
Stability:
Stable

COFACTOR support

Maintainers

  • Yang Zhang <>
  • Peter Freddolino <>
  • Yang Zhang <>
  • Peter Freddolino <>

Credits

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Publications

Institution(s)

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA

Funding source(s)

Supported by the National Institute of General Medical Sciences [GM083107, GM116960, GM097033]; NSF [DBI1564756].

Link to literature

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