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the Clusters of Orthologous Groups of proteins COGs


Alternative name: COG database | the Clusters of Orthologous Groups of proteins COGs

Provides clusters of orthologous groups (COGs) and updated annotation of those COGs. COGs is a database where organisms are sorted according to the NCBI Taxonomy database. Each gene entry in a COG is now denoted by its gene index (gi) number in the NCBI protein database and is linked to the respective entry in the NCBI’s RefSeq database. It concentrates on prokaryotes (bacteria and archaea).

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COGs classification

COGs specifications

Restrictions to use:
Data access:
File download, Browse
Community driven:
User data submission:
Not allowed


  • KOGs
  • arCOGs
  • NCVOGs
  • mimiCOOGs
  • POGs
  • COG software

COGs support


  • COG Team <>
  • Yuri Wolf <>
  • Eugene Koonin <>


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National Center for Biotechnology Information, NLM, National Institutes of Health, Bethesda,

Funding source(s)

Supported by the NIH Intramural Research Program at the National Library of Medicine, US Department of Health and Human Services.

Link to literature

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