Predicts and analyzes combination antibody neutralization scores using IC50 and/or IC80 for individual antibodies. CombiNaber is a web-tool that predict bnAb combination neutralization results from single bnAb neutralization data using either “Bliss-Hill” (BH) or additive models and perform systematic analysis. It provides the user with the best candidate combinations for their panel. The predicted scores are systematically compared for all single antibodies and 2, 3 and 4 antibody combinations analyzed.
Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA; Santa Fe Institute, Santa Fe, NM, USA; Division of Medical Virology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town and NHLS, Cape Town, South Africa; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Surgery, Duke University Medical Center, Durham, NC, USA; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA; University of KwaZulu-Natal, Durban Department of Immunology and Microbial Science, Durban, South Africa; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa; The Scripps Research Institute, La Jolla, CA, USA; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA; National Institute for Communicable Diseases (NICD), NHLS, University of the Witwatersrand, Johannesburg, South Africa
CombiNAber funding source(s)
This work was supported by the Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (CAVD) grant #1032144, and in part from the intramural research program of the Vaccine Research Center (VRC), NIAID, NIH, and by the Center for Nonlinear Studies (CNLS) at Los Alamos National Laboratory.