Integrates analysis and visualization of RNAi screen data. CARD allows the user to seamlessly carry out sequential steps in a rigorous data analysis workflow, including normalization, off-target analysis, integration of gene expression data, optimal thresholds for hit selection and network/pathway analysis. CARD also uses cutting-edge data visualization techniques that allow users to interact dynamically with the figures and tables displayed on the web-browser to facilitate the hit selection process.
Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MA, USA; Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia; ICCB-Longwood Screening Facility, Harvard Medical School, Boston, MA, USA; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC, Australia; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA
CARD funding source(s)
This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, the National Center for Advancing Translational Sciences and Harvard Medical School. It was also supported by the Victorian Centre for Functional Genomics, the Australian Cancer Research Foundation (ACRF), the Victorian Department of Industry, Innovation and Regional Development (DIIRD), the Australian Phenomics Network (APN) and by funding from the Australian Government’s Education Investment Fund through the Super Science Initiative, the Australasian Genomics Technologies Association (AMATA), the Brockhoff Foundation and the Peter MacCallum Cancer Centre Foundation.