Detects SNPs and short indels from high-throughput sequencing of pooled DNA samples. CRISP has been primarily developed to analyze data from "artificial" DNA pools, i.e. pools generated by equi-molar pooling of DNA from multiple individual samples. CRISP leverages sequence data from multiple such pools to detect both rare and common variants. Note that the method is not designed for variant detection from a single pool. CRISP was developed for targeted disease association studies in humans but may work well for other applications.