Combines toxicity and efficacy of candidate drugs, expansibility of data and algorithms, and customizes reference gene profiles. It is able to connect query gene expression profile signatures with a selected reference database. The tool permits the user to perform a drug efficacy analysis to identify some known mechanisms of drug action or generate new predictions.
Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, China; Center of Excellence in Bioinformatics and Life Sciences, the State University of New York at Buffalo, Buffalo, NY, USA; Basic Medical College, Beijing University of Chinese Medicine, Beijing, China; Digestive Diseases and Nutrition Center, Department of Pediatrics, The State University of New York at Buffalo, Buffalo, NY, USA; Genome, Environment, and Microbiome Community of Excellence, The State University of New York at Buffalo, Buffalo, NY, USA; Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
CMC funding source(s)
Supported by National Natural Science Foundation of China 31200986, 41530105, the Fundamental Research Funds for the Central Universities 10247201546, 2000219083, a departmental start-up fund and the Peter and Tommy Fund, Inc., Buffalo, NY.