Gene expression connectivity mapping software tools | Drug discovery data analysis
Here, we surveyed bioinformatics software tools for exploring gene expression connectivity mapping. Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Connectivity mapping is a process to recognize novel pharmacological and toxicological properties in small molecules by comparing their gene expression signatures with others in a database.
A Java application designed to undertake connectivity mapping tasks. sscMap is bundled with a default collection of reference gene-expression profiles based on the publicly available dataset from the Broad Institute Connectivity Map 02, which includes data from over 7000 Affymetrix microarrays, for over 1000 small-molecule compounds, and 6100 treatment instances in 5 human cell lines. In addition, the application allows users to add their custom collections of reference profiles and is applicable to a wide range of other 'omics technologies.
A web-server used to identify Anatomical Therapeutic Chemical (ATC) class. iATC-mISF was developed by incorporating the information of chemical-chemical interaction, the information of the structural similarity, and the information of the fingerprintal similarity. To maximize the convenience for most experimental scientists, a step-by-step guide was provided, by which users can easily get their desired results without needing to go through the complicated mathematical equations.
Provides in silico prediction of drug-induced changes of gene expression profiles based on structural formula. DIGEP-Pred is a web application where predictions are based on Prediction of Activity Spectra for Substances (PASS) technology and training sets. These techniques are created on the basis of data on drug-induced changes of gene expression profiles retrieved from Comparative Toxicogenomics Database (CTD), Connectivity Map Database (CMD) and L1000 Project.
Combines toxicity and efficacy of candidate drugs, expansibility of data and algorithms, and customizes reference gene profiles. It is able to connect query gene expression profile signatures with a selected reference database. The tool permits the user to perform a drug efficacy analysis to identify some known mechanisms of drug action or generate new predictions.
A fully configurable framework for co-expressed gene set enrichment analysis. By combining pathway analysis and drug repositioning analysis, Cogena provides a unique approach to imply the drug mode of action in a disease context, which is important to the translational development of computationally repositioned drugs. Cogena is a powerful tool for co-expressed gene set enrichment analysis, including pathway analysis and drug repositioning.
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