ConoMass specifications


Unique identifier OMICS_26900
Name ConoMass
Alternative names ConoMass1, ConoMass2
Interface Web user interface
Restrictions to use None
Input data A protein or a nucleic sequence for the first step or a mass spectrometry file and a PTF differential mass file or a PTM differential mass computation ID for the second step.
Input format FASTA,(CSV,RTF,TXT+RAW)
Output data A table of the identified peptides, and comparison of the theoretical and experimental masses.
Output format XLS,CSV
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline David Craik <>
  • person_outline Quentin Kaas <>

Additional information

Publication for ConoMass

ConoMass in publications

PMCID: 5877649
PMID: 29522462
DOI: 10.3390/ijms19030788

[…] unpredictable incorporation of ptms often confounds the automated integration of transcriptomic and proteomic data. current search engines, such as proteinpilot™ (sciex, washington, dc, usa) and the conomass tool of conoserver, enable the detection of common conotoxin ptms including disulfide bonds, c-terminal amidation, pyroglutamylation, glutamate carboxylation, proline hydroxylation, valine […]

PMCID: 4488696
PMID: 26110505
DOI: 10.3390/toxins7062159

[…] large number of ptms. the latest developments in the field been have been recently reviewed [,], and we will focus on bioinformatics methods specifically made to analyze venom content. a tool called conomass, accessible from the conoserver website, uses a brute force approach to match reconstructed peptide masses from ms data with toxin masses predicted from transcriptome analysis [,]. conomass […]

PMCID: 3721229
PMID: 23783403
DOI: 10.3390/md11062203

[…] peptides, also called conotoxins, contain one or more disulphide bridges. in this study, we are able to identify only disulfide-rich peptides by mass-matching (). these represented only 5% of all “conomass” detected. the 95% of conomasses not identified may thus represent an interesting pool of new conopeptides. databases from national center for biotechnology information (ncbi), uniprotkb, […]

PMCID: 3705362
PMID: 23455513
DOI: 10.3390/md11030623

[…] is available online [,,]. the conoserver provides up-to-date information on the sixteen known conopeptide gene superfamilies and currently contains data for over 3500 conopeptide sequences. the conomass tool matches peptide masses predicted from transcripts with a list of masses obtained experimentally by proteomics analysis of cone snail venoms. several post-translational modifications […]

To access a full list of publications, you will need to upgrade to our premium service.

ConoMass institution(s)
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
ConoMass funding source(s)
Supported by Australian National Health and Medical Research Council NHMRC (Grant no. 631457) and the Australian Research Council (DP1093115).

ConoMass reviews

star_border star_border star_border star_border star_border
star star star star star

Be the first to review ConoMass