ConQuass statistics

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ConQuass specifications

Information


Unique identifier OMICS_11947
Name ConQuass
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Perl, R
Computer skills Advanced
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Nir Ben-Tal <>

Information


Unique identifier OMICS_11947
Name ConQuass
Interface Web user interface
Restrictions to use None
Input format PDB
Computer skills Basic
Stability Beta
Maintained Yes

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Maintainer


  • person_outline Nir Ben-Tal <>

Publication for ConQuass

ConQuass in publications

 (4)
PMCID: 4256070
PMID: 25474149
DOI: 10.1371/journal.pcbi.1003976

[…] the loops connecting s1–s2, s2–s3 and s5-p-loop, were refined with the rosetta loop modeling application , . rosetta created 1,000 decoys for each loop. the decoys were then evaluated using the conquass method . conquass is based on the anticipation that evolutionarily conserved amino acids are buried in the protein and that variable residues are exposed to the environment, and assigns […]

PMCID: 4147951
PMID: 25093911
DOI: 10.1021/bi500637f

[…] elements., further filtering of the models using conservation analysis was considered but found not to be reliable for the sert terminal domains. conservation analysis (used in, e.g., proq2 or conquass model quality assessment functions) assigns a model a higher score if the variable residues are exposed and conserved residues are buried. however, we estimate that 60% of the residues […]

PMCID: 3514729
PMID: 23148261
DOI: 10.1085/jgp.201210878

[…] such that more evolutionarily variable residues face away from the protein in the corresponding model (fig. s4). a quantitative measure of the extent to which conserved residues are buried, the conquass score (), has a value of 0.154 ± 0.005 for the top 10 models of clc-ka, which is a statistically significant improvement compared with models based on the previous alignment, whose scores […]

PMCID: 3359163
PMID: 22452850
DOI: 10.1186/1743-422X-9-75

[…] between the cαs, and selecting the model most representative of the largest group. the lateral chains were added, refined, and relaxed later on the model. validation and ranking with the consurf and conquass software, respectively, were then performed. the final selection was made with consideration of previously reported biochemical data, the secondary structures predicted by psipred, […]


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ConQuass institution(s)
Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel

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