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Constellation Map specifications


Unique identifier OMICS_12633
Name Constellation Map
Interface Web user interface
Restrictions to use Academic or non-commercial use
Input format gct, cls
License MIT License
Computer skills Basic
Version 1.2
Stability Stable
Maintained Yes



  • person_outline Jill P. Mesirov

Publication for Constellation Map

Constellation Map citation


Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies

PMCID: 5650272
PMID: 29088717
DOI: 10.18632/oncotarget.20621

[…] using this threshold, we identified 39 drugs, 38 of which were more effective in ttf1-low cell lines., we subsequently applied an in-house curated drug-target database to generate a “drug-target constellation map” (dtect map) of the 39 drugs with differential activity in cell lines with high versus low ttf1 levels (figure ). similar to the analysis of drug sensitivity between groups 1 and 2, […]

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Constellation Map institution(s)
Broad Institute of MIT and Harvard, Cambridge, MA, USA; Bioinformatics Program, Boston University, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Division of Hematology/Oncology, Children’s Hospital, Harvard Medical School, Boston, MA, USA
Constellation Map funding source(s)
Supported by National Human Genome Research Institute, award number U41HG007517, and National Institute of General Medical Sciences, award number R01GM074024, of the National Institutes of Health; Bill & Melinda Gates Foundation, grant number OPP50092 and National Institute of Allergy and Infectious Diseases, U19AI090023, of the National Institutes of Health.

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