CoPIT specifications


Unique identifier OMICS_13624
Name CoPIT
Alternative name co-interacting protein identification technology
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Java
Computer skills Medium
Stability Stable
Source code URL
Maintained Yes


No version available


  • person_outline John R. Yates

Publication for co-interacting protein identification technology

CoPIT citations


Cardiovascular proteomics in the era of big data: experimental and computational advances

PMCID: 5137214
PMID: 27980500
DOI: 10.1186/s12014-016-9124-y

[…] ecent examples provided important context to systems genetics experimental data to evidence the involvement of an interacting cilia protein network in congenital heart diseases []. More recently, the CoPIT method extends the scope of comparison to degrees of interactions among samples across cell states with more rigorous statistics, and is particularly notable in its suitability for quantifying d […]


ΔF508 CFTR interactome remodeling promotes rescue of Cystic Fibrosis

PMCID: 4826614
PMID: 26618866
DOI: 10.1038/nature15729

[…] Protein lysates were prepared as described for CoPIT, denatured in SDS sample buffer for 15 min at 37°C for detecting CFTR or for 5 min at 95°C, separated by SDS-PAGE and transferred onto nitrocellulose (Protran, Schleicher&Schuell, Germany). The […]

CoPIT institution(s)
Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA; Department of Physics, Albert-Ludwigs-University Freiburg, Freiburg, Germany
CoPIT funding source(s)
This work was supported by NIH grants 5R01HL079442, P01AG031097, P41 RR011823, DK075295 and HHSN268201000035C, and CFF mass spectrometry fellowship BALCH050X6.

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