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COSMIC specifications


Unique identifier OMICS_00082
Alternative name Catalogue Of Somatic Mutations In Cancer
Restrictions to use Academic or non-commercial use
Community driven No
Data access File download, Browse
User data submission Allowed
Version 86
Content license CC Attribution-NonCommercial
Maintained Yes


  • Primates
    • Homo sapiens



  • person_outline COSMIC Team
  • person_outline John Tate

Additional information A beta version is available at

Publications for Catalogue Of Somatic Mutations In Cancer



2006 Br J Cancer
PMCID: 2361125
PMID: 16421597
DOI: 10.1038/sj.bjc.6602928

COSMIC citations


Clinical application of targeted next generation sequencing for colorectal cancer patients: a multicentric Belgian experience

PMCID: 5945518
PMID: 29755687
DOI: 10.18632/oncotarget.25099

[…] , ]. Moreover, each mutation was verified in the Integrative genome viewer (IGV) from the Broad Institute ( Only mutations reported in the COSMIC (Sanger Institute Catalogue of Somatic Mutations in Cancer) database ( were taken into account, and silent or intronic mutations were not reported. A case was considered to be without mut […]


Helicase like transcription factor expression is associated with a poor prognosis in Non Small Cell Lung Cancer (NSCLC)

BMC Cancer
PMCID: 5902896
PMID: 29661164
DOI: 10.1186/s12885-018-4215-y

[…] ata from The Cancer Genome Atlas (TCGA) project and other cancer genome profiling initiatives ( Additional cancer genome profiling data were obtained from the Catalogue of Somatic Mutations in Cancer (; []).To obtain gene expression estimates for individual mRNA forms, paired-end RNAseq raw read data from the TCGA project we […]


Sensitivity to sequencing depth in single cell cancer genomics

Genome Med
PMCID: 5901877
PMID: 29661213
DOI: 10.1186/s13073-018-0537-2

[…] eplicates that were also identified in the original single-cell datasets (“somatic precision”). In addition, we repeated the recall analysis focusing only on the somatic SNVs already described in the Catalogue Of Somatic Mutations In Cancer (COSMIC) database [] and on the non-synonymous SNVs previously detected (Additional file : Table S2).Single-cell copy-number variants (CNVs) were identified wi […]


Metaplastic breast cancer in a patient with neurofibromatosis type 1 and somatic loss of heterozygosity

PMCID: 5880258
PMID: 29449315
DOI: 10.1101/mcs.a002352

[…] aSVM, MutationAssessor, Condel, and CADD.Somatic SNVs were annotated using ANNOVAR (). Their prior identification was checked using databases including ENSEMBL (, dbSNP snp150, Catalogue of Somatic Mutations in Cancer hg19 v. 68 (COSMIC;, and Cancer Driver Log (CanDL; ().To calculate the VAF for each SNV identi […]


Expanding horizons: new roles for non canonical RNA binding proteins in cancer

PMCID: 5894799
PMID: 29216518
DOI: 10.1016/j.gde.2017.11.006

[…] potential roles in cancer, we compared the census of human RBPs collected in system-wide studies by RNA interactome capture (RNA-IC) [] and RBDmap [] with cancer-associated proteins annotated in the Catalogue of Somatic Mutations in Cancer (COSMIC) cancer gene census list [], Online Mendelian Inheritance in Man (OMIM) [], or related processes in Gene Ontology (GO) []. RNA-IC employs ultraviolet c […]


HER2 is not a cancer subtype but rather a pan cancer event and is highly enriched in AR driven breast tumors

PMCID: 5791377
PMID: 29382369
DOI: 10.1186/s13058-018-0933-y

[…] sis Toolkit (GATK) for variant calling. Tumor-specific variants were obtained by comparing tumor and matched normal, excluding polymorphic variants from dbSNP version 132 that are not reported in the Catalogue of Somatic Mutations in Cancer (COSMIC) database.Infinium HumanMethylation450 Beadchip methylation data are from NCI's Genomic Data Commons ( Data were processed with […]


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COSMIC institution(s)
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK; Astex Pharmaceuticals, Cambridge, UK; Open Targets, Wellcome Genome Campus, Hinxton, Cambridge, UK
COSMIC funding source(s)
Supported by the Wellcome Trust grant [206194]; AstraZeneca, Astex Pharmaceuticals, Bayer Pharmaceuticals and Open Targets.

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