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CPhos specifications


Unique identifier OMICS_20954
Name CPhos
Software type Application/Script
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Fahad Saeed <>


Unique identifier OMICS_20954
Name CPhos
Software type Pipeline/Workflow
Interface Graphical user interface
Restrictions to use None
Input data Phosphopeptides and species.
Output data A summary page, list of phosphopeptides, phosphosites, phosphoproteins, orthologs, sequence alignments, and conservation scores.
Output format CSV
Operating system Unix/Linux, Mac OS, Windows
Programming languages Java
Computer skills Medium
Version 1.3
Stability Stable
Maintained Yes



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  • person_outline Fahad Saeed <>

Publication for CPhos

CPhos in publications

PMCID: 5488304
PMID: 28508520
DOI: 10.1002/anie.201701691

[…] sites, with n‐butylzinc chloride (figure ). both catalyst systems were unselective and generated bis‐alkylated products in mixtures with starting material. interestingly, while the biarylphosphine (cphos) system predominantly gave rise to the product resulting from c−otf and c−br alkylation, the nhc (ipent) system showed simultaneous c−br and c−cl alkylation instead. both ligands are generally […]

PMCID: 5010044
PMID: 27402227
DOI: 10.15252/embj.201694071

[…] and then imaged in extracellular buffer as described previously (malmersjö et al, )., to assess the conservation of phosphorylation sites among different species, we used the standalone versions of cphos (zhao et al, ) (http://helixweb.nih.gov/cphos) to calculate a score for each identified phosphorylation site in our phosphoproteomics data. only phosphorylation sites with a perfect […]

PMCID: 4821552
PMID: 27046079
DOI: 10.1371/journal.pone.0152809

[…] with a database of experimentally-determined phosphorylation sites and a phosphorylation site prediction algorithm. another software program devoted to the evolution of phosphorylation sites is cphos, which—based on the assumption that functional phosphorylation sites are more likely to be conserved than non-functional sites—aids the user in identifying functional phosphorylation sites […]

PMCID: 4523861
PMID: 26239621
DOI: 10.1038/srep12829

[…] are unique to this study (). 5191 of the identified phosphorylation sites had a phosphors score above 80. to determine the potential functional significances of the phosphorylation sites, we used cphos. the majority of sites had a site conservation score greater than 0.9 (supplemental ) indicating that they were highly conserved sites between species and evolution and suggesting […]

PMCID: 4516315
PMID: 26079043
DOI: 10.1021/acs.jmedchem.5b00606

[…] of note in this part is an optimization of the preparation of 1-phenylethylzinc chloride using the lithium chloride, dibromoethane, and trimethysilyl chloride-based protocol− as well as the use of cphos instead of xphos in an attempt to lessen the extent of β-elimination possible with (1-phenylethyl)zinc chloride. concerning the antiviral effects of these compound, […]

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CPhos institution(s)
National Heart, Lung, and Blood Institute (NHLBI), Epithelial Systems Biology Laboratory, National Institutes of Health (NIH), Bethesda, MD, USA
CPhos funding source(s)
Supported by the Intramural Budget of the NHLBI (NHLBI Project no. Z01-HL- 001285).

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