CPLEX specifications


Unique identifier OMICS_13179
Software type Package/Module
Interface Command line interface
Restrictions to use None
Input data The algorithm requires a directed graph that represents the biological network G = (V, E) and scores for each node.
Operating system Unix/Linux, Windows
Computer skills Advanced
Version 12.5
Stability Stable
Maintained Yes


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  • person_outline Christina Backes <>

Publication for CPLEX

CPLEX in publications

PMCID: 5929516
PMID: 29715302
DOI: 10.1371/journal.pone.0195927

[…] mixed integer linear program (milp). to evaluate the validation and effectiveness of the proposed model and solution algorithm, several scenarios are designed and also resolved to optimality by cplex. results demonstrate that (i) detailed route plan associated with passenger assignment to meet points can be obtained with en-route delay savings; (ii) as compared to cplex, the meta-heuristic […]

PMCID: 5919440
PMID: 29698482
DOI: 10.1371/journal.pone.0195545

[…] an o(log m)-approximation of opt., we evaluated the performance of both ilpminppi and greedyminppi using both synthetic data and real protein-protein interaction data. an integer programming solver, cplex interactive optimizer (http://www-01.ibm.com/software/commerce/optimization/cplex-optimizer/) was used to compute an exact optimal solution and ‘epi’ library (version 1.1.67) in r […]

PMCID: 5923651
PMID: 29584679
DOI: 10.3390/ijerph15040609

[…] in this paper, along with the previous used solver, dobss, in the previous paper, is a milp that faces a np-hard problem. a number of well known, efficient solution packages or software (e.g., cplex, yalmip, matlab) for milps can be used to solve this problem, and their calculation performances rely on the number of integer variables. specifically, dobss considers |q||l| integer variables […]

PMCID: 5861505
PMID: 29560822
DOI: 10.1186/s12918-018-0542-5

[…] obtainable while solving problem (eq. ) for jth reaction at kth upregulation/downregulation levels. all the optimization problems were solved using the gams ide software version 22.4 with ibm ilog cplex solver., since optimality assumption based fba algorithms ignores the regulatory consideration while strain designing, we implemented transcriptomics-based strain optimization tool (tsot) [] […]

PMCID: 5856752
PMID: 29549287
DOI: 10.1038/s41598-018-23051-9

[…] linear programming problem. this can be done efficiently for even millions of variables with the interior point method. in this paper, a general linear programming solver, available in the ibm ilog cplex optimization studio [https://www-01.ibm.com/software/commerce/optimization/cplex-optimizer/], is utilized., next, results from brain (hcp) and phantom (fibercup) datasets are presented […]

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CPLEX institution(s)
Department of Human Genetics, Saarland University, Homburg/Saar, Germany; Scientific Consilience, Starterzentrum, Saarland University, Saarbrücken, Germany; Life Sciences Group, Centrum Wiskunde & Informatica, Amsterdam, Netherlands; Center for Bioinformatics, Saarland University, Saarbrücken, Germany; Wilhelm Schickard Institute for Computer Science, Eberhard Karls University, Tübingen, Germany; Roche Diagnostics GmbH, Pharma Research Scientific Informatics, Penzberg, Germany; Machine Learning Group, Saarland University, Saarbrücken, Germany; Siemens Healthcare, Strategy, Erlangen, Germany; Roche Diagnostics GmbH, Discovery Oncology, Penzberg, Germany
CPLEX funding source(s)
This work was supported by the DFG Priority Program SPP 1335: LE 952/3-1, KA 812/13-1.

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