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CRAM | Storage of high throughput DNA sequencing data using reference-based compression

A framework technology comprising file format and toolkit in which we combine highly efficient and tunable reference-based compression of sequence data with a data format that is directly available for computational use. This compression method is tunable: The storage of quality scores and unaligned sequences may be adjusted for different experiments to conserve information or to minimize storage costs, and provides one opportunity to address the threat that increasing DNA sequence volumes will overcome our ability to store the sequences.

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CRAM forum

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CRAM classification

CRAM specifications

Unique identifier:
OMICS_00952
Interface:
Command line interface
Operating system:
Unix/Linux
Computer skills:
Advanced
Stability:
Stable
Software type:
Framework/Library
Restrictions to use:
None
Programming languages:
Java
Version:
2.1
Maintained:
Yes

CRAM distribution

versioning

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Credits

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Publications

Institution(s)

EMBL-Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK

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