CRAM specifications


Unique identifier OMICS_00952
Software type Framework/Library
Interface Command line interface
Restrictions to use None
Input format FASTA
Operating system Unix/Linux
Programming languages Java
Computer skills Advanced
Version 2.1
Stability Stable
Maintained Yes


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CRAM articles

CRAM citations

PMCID: 5522380

[…] [1]., as summarized in table 1, the alignment pipeline started with 63 744 gigabases of low-coverage sequence and 28 152 gigabases of wes sequence. the total amounts of aligned sequence in the final cram files are slightly larger—66 437 and 30 901 gigabases, respectively—because some of the reads are mapped to multiple locations such as the primary chromosomal region and its corresponding alt […]

PMCID: 3832420

[…] but practical. another key weakness of the bam format is that bam files require approximately the same amount of storage as the unaligned reads, for each alignment represented in the format., the cram format, developed for the european nucleotide archive, was developed to try and compress hts alignments better than can be achieved with bam. cram achieves strong compression of alignment files […]

CRAM institution(s)
EMBL-Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK

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