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CRASP specifications


Unique identifier OMICS_25741
Alternative name correlation analysis of protein sequences
Interface Web user interface
Restrictions to use None
Input format FASTA
Computer skills Basic
Version 1.1.0
Stability Stable
Maintained Yes


  • person_outline Dmitry Afonnikov
  • person_outline Nikolay Kolchanov

Publication for correlation analysis of protein sequences

CRASP citations


SubVis: an interactive R package for exploring the effects of multiple substitution matrices on pairwise sequence alignment

PMCID: 5490468
PMID: 28674656
DOI: 10.7717/peerj.3492

[…] r-to-pair substitution matrices. However, it is designed for a specific custom matrix type, does not provide standard matrices, and lacks features that facilitate comparison among different matrices. CRASP () is a web-accessible tool that takes protein family sequence alignments, a phylogenetic tree or other weights, physicochemical characteristics, and conservation filters as input. The output co […]


Origins and Evolution of WUSCHEL Related Homeobox Protein Family in Plant Kingdom

Sci World J
PMCID: 3913392
PMID: 24511289
DOI: 10.1155/2014/534140
call_split See protocol

[…] Analysis of pairwise positional correlations was obtained from the Correlation Analysis of Protein Sequences (CRASP) database with the default parameter setting. […]


The Role of Insulin C Peptide in the Coevolution Analyses of the Insulin Signaling Pathway: A Hint for Its Functions

PLoS One
PMCID: 3531361
PMID: 23300796
DOI: 10.1371/journal.pone.0052847

[…] (e.g., charge, volume, polarity, and hydrophobicity) , allows inferences to be made about the structural–functional role of residues at these positions and to predict protein structure , . The CRASP (Correlation analysis of protein sequences) program is based on estimation of the correlation coefficient between the values of a physicochemical parameter at a pair of positions of sequence alignment. […]


Sequence Complexity of Chromosome 3 in Caenorhabditis elegans

Adv Bioinformatics
PMCID: 3418640
PMID: 22919380
DOI: 10.1155/2012/287486

[…] been observed and measured in pathology and cancer models [, ], the study of branching blood vessels, or the irregularity of the contours of tumor cells [, ], the analysis of complete genomes [], the correlation analysis of protein sequences [] tissue pathology [], in exons, introns [], and nuclei [], and it is involved in blood cancer [, ]. […]


Hyperdimensional Analysis of Amino Acid Pair Distributions in Proteins

PLoS One
PMCID: 3235099
PMID: 22174733
DOI: 10.1371/journal.pone.0025638

[…] open source tools or through user friendly interfaces. Only a few programs have been implemented to date on the web –. Some programs can be downloaded for local usage, such as PlotCor , CorrMut and CRASP . CysView is a web-based application tool that displays cysteine connectivity patterns in proteins . ESBRI is a web tool which analyses the salt bridges in a protein structure . However, the gen […]


Positive and Negative Design in Stability and Thermal Adaptation of Natural Proteins

PLoS Comput Biol
PMCID: 1829478
PMID: 17381236
DOI: 10.1371/journal.pcbi.0030052
call_split See protocol

[…] n a) by using Kalign Web-server for multiple alignment of protein sequences (, []).Correlated substitutions in the multiple alignments were determined by using the CRASP program (, []). The CRASP program gives the correlation coefficient between the values of physicochemical parameters at a pair of positions of seque […]


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CRASP institution(s)
Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia; The Novosibirsk State University, Novosibirsk, Russia
CRASP funding source(s)
Supported by grants from the Russian Foundation for Basic Research (03-07-96833-p2003, 03-07-96833) and the Siberian Branch of the Russian Academy of Sciences (project No. 148, 119), the Russian Ministry of Industry, Sciences and Technologies (No., subcontract 28/2003), MCB RAS (No. 10.4), the CRDF and the Ministry of Education of the Russian Federation within the Basic Research and Higher Education Program (Y1-B-08-20, NO-008-X1).

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