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The simplicity of site-specific genome targeting by type II clustered, regularly interspaced, short palindromic repeat (CRISPR)-Cas9 nucleases, along with their robust activity profile, has changed the landscape of genome editing. These favorable properties have made the CRISPR-Cas9 system the technology of choice for sequence-specific modifications in vertebrate systems.
(Bolukbasi et al., 2016) Creating and evaluating accurate CRISPR-Cas9 scalpels for genomic surgery. Nat Methods.