bookmark DeepCpf1 New Predicts AsCpf1 (Cpf1 from Acidaminococcus sp. BV3L6) activity based on target sequence composition. DeepCpf1 is a web application that performs with a 34-bp target sequence and produces a regression score that correlates with AsCpf1 activity. It learns informative representations of target sequences relevant to AsCpf1 activity profiles. It works in two steps: (1) model selection and pre-training of the entire architecture; and (2) fine-tuning with endogenous target data considering an additional chromatin accessibility input.