CRISPR-FOCUS specifications

Unique identifier:
OMICS_21752
Interface:
Web user interface
Input data:
An official gene symbol and a RefSeq ID.
Programming languages:
Python
Stability:
Stable
Software type:
Application/Script
Restrictions to use:
None
Output data:
A unique ID for each sgRNA within result file, a sgRNA sequence, chromosome name where the target sequence is located, the start coordinate of sgRNA sequence (1-based), the end coordinate of sgRNA sequence (1-based), Strand information, either + or - , the efficiency score of sgRNA sequence, the conservation score of sgRNA sequence, the specificity score of sgRNA sequence, number of putative off-target loci (in terms of perfect match) which hit non-exon region within genome, number of putative off-target loci (in terms of perfect match) which hit exon but non-coding region within genome, and number of putative off-target loci (in terms of perfect match) which hit coding region within genome.
Computer skills:
Basic
Maintained:
Yes
  • Animals
    • Homo sapiens
    • Mus musculus

CRISPR-FOCUS support

Maintainers

  • Liu Shirley <>
  • Zhi Chen <>
  • Wei Li <>

Additional information

http://cistrome.org/crispr-focus/help.html

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Publications

Institution(s)

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China; Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, China; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA, USA

Funding source(s)

Supported by National Natural Science Foundation of China, No. 31401104; and National Natural Science Foundation of China Grant 31329003 and NIH R01 HG008927.

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