Allows rapid identification of sgRNA target sequences in the Chinese hamster ovary (CHO-K1) genome. The CRISPy tool identified 1,970,449 CRISPR targets divided into 27,553 genes and lists the number of off-target sites in the genome. The proven functionality of Cas9 to edit CHO genomes combined with the CRISPy database have the potential to accelerate genome editing and synthetic biology efforts in CHO cells.
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Horsholm, Denmark; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA
CRISPy funding source(s)
This work was supported by The Novo Nordisk Foundation.
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