Crosstalk event detection software tools | Post-translational modification data analysis
The structural, functional, and mechanistic characterization of several types of post-translational modifications (PTMs) is well-documented. PTMs, however, may interact or interfere with one another when regulating protein function. Yet, characterization of the structural and functional signatures of their crosstalk has been hindered by the scarcity of data.
A bioinformatic software tool to predict the cross-talk/interplay between two post-translational modification sites within a protein, by abstracting multiple features and classifying with a naive Bayes model. The features include sequence distance, structural distance, disordered region location, residue co-evolution, and modification co-evolution.