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Crosstalk event detection software tools | Post-translational modification data analysis

The structural, functional, and mechanistic characterization of several types of post-translational modifications (PTMs) is well-documented. PTMs, however, may interact or interfere with one another when regulating protein function. Yet, characterization of the structural and functional signatures of their crosstalk has been hindered by the scarcity of data.

Source text:
(Pejaver et al., 2014) The structural and functional signatures of proteins that undergo multiple events of post-translational modification. Protein Sci.

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A sequence-based predictor of potential post-translational modification (PTM) sites in proteins. It consists of 34 ensembles of logistic regression models, trained separately on a combined set of 126,036 non-redundant experimentally verified sites for 23 different modifications, obtained from public databases and an ad-hoc literature search. Areas under the ROC curve (AUCs) were estimated to range from ~60 to 97%, depending on the type of PTM. ModPred is a useful tool in guiding biological experiments and data interpretation.
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