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|Interface||Command line interface|
|Restrictions to use||None|
|Output data||z-score, p-value, false discovery rate, a test of normality for the N/A distributions|
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- person_outline Erik Sonnhammer
Publication for CrossTalkZ
FunGeneNet: a web tool to estimate enrichment of functional interactions in experimental gene sets
[…] ne networks with random networks is an alternative approach for determining functional connectivity in experimental sets of genes/proteins [–]. In the work of McCormack et al. , a stand-alone tool, CrossTalkZ, was developed to assess the statistical significance of inter and intra-connectivity (crosstalk enrichment) between or within gene sets. CrossTalkZ uses the FunCoup database for the recons […]
Network Analysis of Functional Genomics Data: Application to Avian Sex Biased Gene Expression
[…] o genes of the same bias, we compared the connection frequencies between the different categories to what is expected by chance alone. For topology-preserving randomization of the network we used the CrossTalkZ program (see ) and performed 100 randomization runs. The results for the embryonic and adult gonads are shown in .In the gonad we found genes of the same sex bias (e.g., male versus male) t […]
Comparative interactomics with Funcoup 2.0
[…] re obtained by complementary approaches, and one wants to test the hypothesis that they are significantly related. This can currently not be done statistically on the website, but a new separate tool CrossTalkZ can perform such tests.Enter gene set identifiers (many types are supported) into the query box.Set network distance to 0 and confidence cut-off to 0.5.Run query. If the subnetwork appears […]
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