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Chromosomal abnormality databases | Genome annotation

Chromosomal abnormality databases | Genome annotation A chromosomal rearrangement (CR) event occurs as a consequence of double-strand breaks (DSBs) of the DNA, followed by abnormal rejoining of the non-homologous ends, producing a new chromosomal arrangement. Alternatively, a CR event can result from crossing-over between repetitive DNA sequences. CR events may lead to disruption of genes and other functional structures. They have been implicated in many tumor and non-tumor human diseases, and are frequently examined in clinical diagnosis, treatment and prognosis.
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