A chromosomal rearrangement (CR) event occurs as a consequence of double-strand breaks (DSBs) of the DNA, followed by abnormal rejoining of the non-homologous ends, producing a new chromosomal arrangement. Alternatively, a CR event can result from crossing-over between repetitive DNA sequences. CR events may lead to disruption of genes and other functional structures. They have been implicated in many tumor and non-tumor human diseases, and are frequently examined in clinical diagnosis, treatment and prognosis.
A database which provides detailed information regarding the exploration of a specific hybrid gene of interest. HYBRIDdb encompasses the bioinformatics analysis of mRNA, EST, cDNA and can be used to identify hybrid transcripts created by chromosomal-mediated translocation and intergenic splicing-mediated gene fusion. The HYBRIDdb database provide genome scientists with insight into potential roles for hybrid genes in human evolution and disease.
Relates chromosomal aberrations to tumor characteristics, based either on individual cases or associations. Mitelman Database provides data manually chosen from the literature. It contains more than 68 000 cases and over 11 000 gene fusions. This database in sub-divided into three parts supplying: data that relates chromosomal aberrations to specific tumor characteristics in individual patient cases; molecular biology and clinical associations; and references.
A database of functional and regulatory elements of cancer-associated fusion events. FARE-CAFE is a database with the combination of the cancer related chromosomal translation events, fusion genes, domains, domain-domain interactions (DDI), protein-protein interactions (PPI), transcription factors(TF) and miRNAs collectively with the consequent experimental information. The significance of this database is currently, there is no database endow with fusion proteins role in terms of PPI and DDI in oncogenesis. This database provides detailed information about cancer related fusion genes regulatory (TFs and their target miRNA) and functional elements (domains, DDIs, PPIs). FARE-CAFE database will helpful to demonstrate clear understanding on molecular mechanism of cancer progression and ultimately pilot to the expansion of novel therapeutic approaches.
An accessible online repository of genetic variation with associated phenotypes that facilitates the identification and interpretation of pathogenic genetic variation in patients with rare disorders. Contributing to DECIPHER is an international consortium of >200 academic clinical centres of genetic medicine and ≥1600 clinical geneticists and diagnostic laboratory scientists. Information integrated from a variety of bioinformatics resources, coupled with visualization tools, provides a comprehensive set of tools to identify other patients with similar genotype-phenotype characteristics and highlights potentially pathogenic genes.
Provides a public platform for investigators to share and compare their molecular cytogenetic data. SKY/M-FISH & CGH Database is open to everyone and all users can view an individual investigator's public data or compare public cases from different investigators. Those wishing to contribute their own data must register and can choose to keep their data private for a period not to exceed two years.
An online database system of cross-referenced information and resources on Brassicaceae taxonomy, systematics, evolution, traits and germplasm resources. Biological material and resources, either collected directly in the wild or held in germplasm collections, are often taxonomically misidentified and are very rarely further characterized and documented. BrassiBase will close these various gaps and provide the full potential of research focusing on the adaptive characters and character trait evolution in the Brassicaceae.