A cancer stem cells (CSCs) database that includes marker genes, CSCs-related genes/microRNAs and functional annotations. The information in the CSCdb was manual collected from about 13,000 articles. The CSCdb provides detailed information of 1769 genes that have been reported to participate in the functional regulation of CSCs and 74 marker genes that can be used for identification or isolation of CSCs. The CSCdb also provides 9475 annotations about 13 CSCs-related functions, such as oncogenesis, radio resistance, tumorigenesis, differentiation, etc. Annotations of the identified genes, which include protein function description, post-transcription modification information, related literature, Gene Ontology (GO), protein-protein interaction (PPI) information and regulatory relationships, are integrated into the CSCdb to help users get information more easily.
School of Information Science and Technology, University of Science and Technology of China, Hefei, China; School of Life Science, University of Science and Technology of China, Hefei, China; Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China
CSCdb funding source(s)
National Natural Science Foundation of China (No. 61571414 and No. 61471331)