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Protocols

CTRP specifications

Information


Unique identifier OMICS_15213
Name CTRP
Alternative name Cancer Therapeutics Response Portal
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Version 2.0
Maintained Yes

Maintainer


  • person_outline Paul Clemons

Publication for Cancer Therapeutics Response Portal

CTRP citations

 (12)
library_books

Discovering drugs to overcome chemoresistance in ovarian cancers based on the cancer genome atlas tumor transcriptome profile

2017
Oncotarget
PMCID: 5777757
PMID: 29383145
DOI: 10.18632/oncotarget.22870

[…] rs in multi-platform TCGA datasets. We provided further validation of these drugs’ sensitivity in additional clinical samples derived from ovarian cancer patients (through AOCS) and in vitro (through CTRP v2).Although survival information has been collected for almost all TCGA samples, the treatment information for each patient is lot sparse, ranging from 40-97% coverage for each disease type to d […]

library_books

De novo mutations implicate novel genes in systemic lupus erythematosus

2017
Hum Mol Genet
PMCID: 5886157
PMID: 29177435
DOI: 10.1093/hmg/ddx407

[…] .His198Gln DNM detected in the C1QTNF4 gene as an alternative method to add support for its potential role in disease. Although its function is rather poorly understood, the protein product, C1QTNF4 (CTRP4) is secreted and may act as a cytokine, as it has homology with TNF and the complement component C1q (). C1QTNF4 has been shown to influence NF-κB activation (), a pathway known to be implicated […]

library_books

Patient derived xenografts undergo murine specific tumor evolution

2017
Nat Genet
PMCID: 5659952
PMID: 28991255
DOI: 10.1038/ng.3967

[…] eens across 503 cell lines (n = 446 with arm-level CNA calls), using the DEMETER algorithm to isolate gene knockdown effects from off-target effects. Drug sensitivity measurements were taken from the Cancer Therapeutics Response Portal (CTRP v2) dataset (downloaded from https://ctd2.nci.nih.gov/dataPortal/). These data represented dose-response curve AUC measures for 887 cell lines (n = 804 with a […]

library_books

Contextualization of drug mediator relations using evidence networks

2017
BMC Bioinformatics
PMCID: 5471944
PMID: 28617226
DOI: 10.1186/s12859-017-1642-8

[…] In this project, we have improved the interpretability of the EDDY-CTRP results by generating evidence networks of the most relevant intermediate genes using the STRING and STITCH knowledge-bases. With these evidence networks and our Cytoscape.js-based user interface […]

library_books

C1q/TNF Related Protein 9 Ameliorates Ox LDL Induced Endothelial Dysfunction via PGC 1α/AMPK Mediated Antioxidant Enzyme Induction

2017
Int J Mol Sci
PMCID: 5485929
PMID: 28587104
DOI: 10.3390/ijms18061097

[…] nized and transferred to 96-well plate at 1 × 104 cells/well. The cells were subjected to serum-deprived medium culture overnight, and then exposed to ox-LDL (100 μg/mL) in the presence or absence of CTRP9 (0.3, 1, 3 μg/mL) for 24 h. Finally, 10 μl of CCK-8 solution was added into each well for 2 h at 37 °C. The absorbance was measured at 450 nm using a microplate reader (SYNERGY H4, BioTek, VT, U […]

library_books

Performance comparison of next generation sequencing platforms for determining HIV 1 coreceptor use

2017
Sci Rep
PMCID: 5301480
PMID: 28186189
DOI: 10.1038/srep42215

[…] steine required for the disulfide bond; (ii) they were not 32–38 amino-acids long; (iii) they contained a stop codon; (iv) they were not sufficiently like the V3 consensus at three typical motifs: a “CTRP”-like signature at the N-terminus, a “GPGR”-like signature at the hairpin crown, or a “QAHC”-like signature at the C-terminus with an identity of 0.5 and 0.75 for substitution and insertion/delet […]

Citations

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CTRP institution(s)
The Broad Institute of Harvard and MIT, Cambridge, MA, USA; Vanderbilt University School of Medicine, Nashville, TN, USA; Columbia University, New York, NY, USA
CTRP funding source(s)
This work was supported by the NCI’s Cancer Target Discovery and Development Network (RC2-CA148399).

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