CUPSAT statistics

Tool stats & trends

Looking to identify usage trends or leading experts?

Protocols

CUPSAT specifications

Information


Unique identifier OMICS_00128
Name CUPSAT
Alternative name Cologne University Protein Stability Analysis Tool
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Dr. Vijaya Parthiban

Publication for Cologne University Protein Stability Analysis Tool

CUPSAT citations

 (37)
library_books

Accurate prediction of functional, structural, and stability changes in PITX2 mutations using in silico bioinformatics algorithms

2018
PLoS One
PMCID: 5903617
PMID: 29664915
DOI: 10.1371/journal.pone.0195971

[…] To assess the performance of eight different stability predictor programs (DUET, SDM, mCSM, I-Mutant3.0, MUpro, iPTREE-STAB, CUPSAT, and iStable) in predicting the effect of missense mutations on PITX2 protein stability, the change in protein stability (ΔΔG) were computed for all 24 PITX2 homeodomain variants (15 functional […]

library_books

Effect of Specific Mutations in Cd300 Complexes Formation; Potential Implication of Cd300f in Multiple Sclerosis

2017
Sci Rep
PMCID: 5648872
PMID: 29051512
DOI: 10.1038/s41598-017-12881-8

[…] shown that changes in the residues within the turns result in variations in protein stability. In order to analyze the effect of substituting arginine 33 in CD300f by a glutamine residue, we used the CUPSAT tool (http://cupsat.tu-bs.de/), which predicts changes in protein stability following point mutations. The prediction model uses amino acid atom potentials and torsion angle distribution to ass […]

library_books

Vermont: a multi perspective visual interactive platform for mutational analysis

2017
BMC Bioinformatics
PMCID: 5606220
PMID: 28929973
DOI: 10.1186/s12859-017-1789-3

[…] ements INPS with a new predictor (INPS-3D) that exploits descriptors derived from the protein structure.iStable, proposed in [], integrates I-Mutant2.0 [], MUPRO [], AUTO-MUTE [], PoPMuSiC2.0 [], and CUPSAT [] through SVM to predict protein stability changes upon single amino acid residue mutations, and it performs better than any single method alone.DUET, presented in [], combines mCSM [] and SDM […]

call_split

Computing disease linked SOD1 mutations: deciphering protein stability and patient phenotype relations

2017
Sci Rep
PMCID: 5498623
PMID: 28680046
DOI: 10.1038/s41598-017-04950-9
call_split See protocol

[…] played an R2 value of 0.25, corresponding to R value of 0.5, and considerably better than any of the other six methods. It was followed by Fold X (R = 0.45) and BeatMusic (R = 0.45), ENCoM (R = 0.4), CUPSAT (R = 0.37), I-Mutant 3.0 (R = 0.24), I-Mutant 2.0 (R = 0.23) and mCSM (R = 0.05). For the representative apo-monomer SOD1structure, 2XJK (Fig. ), Fold X displayed an R value of 0.53 followed by […]

library_books

A novel PEX1 mutation in a Moroccan family with Zellweger spectrum disorders

2017
Hum Genome Var
PMCID: 5390255
PMID: 28446956
DOI: 10.1038/hgv.2017.9

[…] Leu1026Pro is predicted to be probably damaging by Polyphen2 and SIFT programs. Using PROVEN and MUTATION TASTER, the variation was found respectively deleterious and disease causing. The MAESTRO and CUPSAT tools predicted the amino acid change destabilizing this protein. A three-dimensional structure was constructed based on the crystal structure of the N-terminal domain of PEX1 AAA-ATPase (PDB I […]

call_split

POLE and POLD1 screening in 155 patients with multiple polyps and early onset colorectal cancer

2017
Oncotarget
PMCID: 5432293
PMID: 28423643
DOI: 10.18632/oncotarget.15810
call_split See protocol

[…] ein stability predictions were performed using Eris (http://troll.med.unc.edu/eris/), PoPMuSiC (http://dezyme.com/en/Software), I-Mutant 2.0 (http://folding.biofold.org/i-mutant/i-mutant2.0.html) and CUPSAT (http://cupsat.tu-bs.de/). […]

Citations

Looking to check out a full list of citations?

CUPSAT institution(s)
Cologne University Bioinformatics Center, International Max Planck Research School, Cologne, Germany

CUPSAT review

star_border star_border star_border star_border star_border
star star star star star

NAGA VENKATA SAI GIRIDHAR REDDY

star_border star_border star_border star_border star_border
star star star star star
Web
SERVICE IS NOT AVAILABLE MAKING INCONVENIENCE TO MY WORK