A manually curated sequence and amino acid motif database gathering all the different phycobilin lyases and related protein sequences available in public databases. CyanoLyase provides an extensive collection of phycobilin lyases and related proteins, classified in clans, subclans, families and subfamilies. The website also gives access to bioinformatic tools to ease the annotation of these sequences in forthcoming genomes of phycobiliprotein-containing organisms. As such, the website will be updated regularly as new data become available and will therefore be a long-term resource. Users can monitor directly from the web interface the latest changes that have occurred in the database using the corresponding scrolldown menu.